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See also: Ribociclib is used to treat hormone-related in women. Ribociclib is used only if your cancer tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells. Ribociclib is used when the cancer has progressed or has spread to other parts of the body after other treatments. Ribociclib is given in combination with another cancer medicine such as () or (). Ribociclib may also be used for purposes not listed in this medication guide.

Before taking this medicine You should not use ribociclib if you are allergic to it, or if you also take. Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using ribociclib.

Tell your doctor if you have ever had: • heart disease or prior; • slow heartbeats; • heart disease or prior heart attack; •; • an electrolyte imbalance (such as low levels of calcium, magnesium, phosphorus, or potassium in your blood); •; • kidney disease; or • signs of infection (fever, chills). Tell your doctor whether or not you have gone through. You may need to have a negative pregnancy test before starting this treatment. Do not use ribociclib if you are pregnant. It could harm the unborn baby.

Use effective to prevent pregnancy while you are using ribociclib and for at least 3 weeks after your last dose. This medicine may affect fertility (ability to have children) in men. Talk with your doctor if you have concerns about this risk. You should not breast-feed while using this medicine and for at least 3 weeks after your last dose. How should I take ribociclib? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Ribociclib is given in a 28-day treatment cycle. You will take the medicine for the first 21 days of each cycle, followed by 7 days off. Your doctor will determine how long to treat you with ribociclib.

Swallow the tablet whole and do not crush, chew, or break it. Take the medicine at the same time each morning, with or without food. If you vomit after taking the medicine, wait until the next day to take your next dose. Do not use a broken or damaged pill.

You may need frequent medical tests to be sure ribociclib is not causing harmful effects. Your cancer treatments may be delayed based on the results. Lks matematika sd kelas 6.

Store ribociclib in the original container at room temperature, away from moisture and heat. Ribociclib side effects Get emergency medical help if you have signs of an allergic reaction:; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); • low white blood cell counts--fever, mouth sores, skin sores,, cough, trouble breathing; or • liver problems--loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, (yellowing of the skin or eyes). Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: • low white blood cells, infections; • cough; •,; •,; • feeling tired; •; or •. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088. Ribociclib dosing information Usual Adult Dose for Breast Cancer: 600 mg orally once a day for 21 consecutive days followed by 7 days off for a complete cycle of 28 days; continue until disease progression or unacceptable toxicity Comments: -Refer to the manufacturer product information for dosing and administration recommendations for the co-administered aromatase inhibitor (e.g., letrozole). -When given with this drug, the recommended dose of fulvestrant is 500 mg administered on Days 1, 15, 29, and once monthly thereafter. Refer to the full prescribing information of fulvestrant. -Pre/perimenopausal women treated with the combination of this drug plus an aromatase inhibitor or fulvestrant should be treated with a luteinizing hormone-releasing hormone (LHRH) agonist according to current clinical practice standards. Uses: -In combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced. -In combination with fulvestrant for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer, as initial endocrine based therapy or following disease progression on endocrine therapy.